Final Year Project (FYP)

Final Year Project (FYP)

This is a part two of an individual research project in connection with a special engineering problem and under the guidance of a faculty member. For FYP, students will be required to submit a Technical Paper to explain in writing about the contents of the project and its significance, the problem statement, objectives, scope, literature review, methodology, results, conclusions and recommendations. 

Besides, for my research projects' is a collaboration between Universiti Teknologi PETRONAS (UTP) and Universiti Malaya (UM)

Europium Doped Calcium Silicate for Biomedical Applications

Calcium silicate (CaSiO3 or CS (Calcium Silicate)) ceramics are being explored for metallic implants in bone regeneration. However, their rapid dissolution rates and poor stability pose challenges. To address this, chemically modified CS ceramics are being developed, with europium (Eu) ions being investigated as a doping option. In this research, Eu-CS (Europium Doped Calcium Silicate) were successfully fabricated, exhibiting improved mechanical properties, lower dissolution rate, and enhanced bioactivity. These pallets have potential applications in bone tissue engineering.

Overview on bone structures

Bones exhibit different structural characteristics at various scales, including particulate, laminar, fibrous, and porous structures (Lakes, 1993). They are composed of osteoblasts (cells responsible for bone formation), osteoclasts (cells involved in bone resorption), as well as various osteoconductive growth factors and molecules. In terms of composition, human bones consist of 60-70% mineral substances, 20-30% collagen and other organic components, with the remaining portion being water (Weiner & Zaslansky, 2005). Table 1 provides a comparison of the chemical composition, crystal structure, and other properties between enamel, dentin, and bone. (Kee, 2023)

Similar Project's Findings & Further Readings 

Synthesis of europium-doped calcium silicate hydrate via hydrothermal and coprecipitation method

Authored by: CC Kee et. al (2021)

In this paper, calcium silicate hydrate doped with various amounts of Eu (Eu–CSH) via hydrothermal and coprecipitation methods have been systematically investigated. The hydrothermal method produced xonotlite while coprecipitation gave 11 Å tobermorite. Regardless of the synthesis method, incorporation of Eu inhibited the crystallite growth and particle size...

Synthesis, characterization and in-vitro biocompatibility of electrophoretic deposited europium-doped calcium silicate on titanium substrate

Authored by: CC Kee et. al (2023)

Europium (Eu) has attracted attention to be incorporated as biologically active ions to achieve different biological and functional properties of biomaterials. In this study, calcium silicate (CS) coatings doped with different amount of Eu (up to 10 mol%) were successfully formed on titanium substrates via electrophoretic deposition...

Synthesis, Mechanical Properties, and in Vitro Biocompatibility with Osteoblasts of Calcium Silicate–Reduced Graphene Oxide Composites

Authored by: Mehdi Mehrali et. al (2014)

Calcium silicate (CaSiO3, CS) ceramics are promising bioactive materials for bone tissue engineering, particularly for bone repair. However, the low toughness of CS limits its application in load-bearing conditions. Recent findings indicating the promising biocompatibility of graphene imply that graphene can be used...

Europium-Doped Calcium Silicate Nanoparticles as High-Quantum-Yield Red-Emitting Phosphors

Authored by: Hyun J.W. et. al (2023)

Europium ion-activated calcium silicate phosphors (Ca2SiO4:Eu3+) with sharp red-light emission were fabricated via the hydrothermal method. The size of Ca2SiO4:Eu3+ phosphors was controlled between 20 and 200 nm by precursor silicate particle sizes. Systematic studies to determine morphology, crystal phase,...

Research Findings, Results & Documentations

Project's Proposal Defense

Calcium silicate (CaSiO3) is recognized for its bioactive properties, making it a promising material for biomedical applications, particularly in bone implants. Its bioactivity stimulates bone growth and integration. Recent studies have shown interest in doping calcium silicate with rare earth elements like europium (Eu) to enhance its properties. 

My Experimental Work

Synthesize europium-doped calcium silicate (Eu-Cs) using precipitation synthesis, Characterize the synthesized material using various techniques including FTIR and XRD and Evaluate the material's bioactivity by assessing hydroxyapatite (HA) formation in simulated body fluid (SBF).

Project's Viva Voce

Europium-doped calcium silicate (Eu-Cs) shows significant promise as a bioactive material for implant applications. Its enhanced bioactivity and structural properties make it a viable candidate for further research and potential clinical applications.